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18 The treatment protocol for TPE consists of removing and retaining a considerable volume of plasma, approximately 1 to 1.5 plasma volume, 17 and returning the necessary cellular components via a colloid or combination colloid/crystallization solution of either fresh frozen plasma (FFP) or albumin

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While complete cartilage regeneration remains beyond current capabilities, peptide support may slow degradation and promote whatever repair potential exists

The animals were housed individually in suspended stainless steel cages, with ad libitum access to food and water [2]